Based on diverse information in the litera- ture, we expected that intravascular laser therapy could be effective in the scope of a redifferentiation therapy. This assumption appears to have been confirmed by the results of our application study. Merely as a result of the sole application of intravas- cular laser therapy, the quantity of circulat- ing tumour cells was reduced and the pa- tient’ s pathological immune response modulated in the direction of the standard. The bioimmunotherapy according to Tall- berg was even more effective in the com- parison. Both procedures applied simulta-neously obviously exhibit synergistic and possibly also additive effects. W e presume that the intravascular laser therapy, like the bioimmunotherapy according to Tallberg, influences the mitochondria-nuclear com- munication by means of a direct effect on the mitochondria, and that malignantly transformed cells redifferentiate to normal somatic cells or transition into apoptosis (additive effect) In addition the known positive immunomodulatory effects of this therapy are likely to be of additional im- portance (synergism). Our patients were all chemotherapeutically maximally pre- treated and have additionally responded well to the intravascular laser treatment. The use of intravascular laser blood irra- diation can therefore also be appropriate during conventional oncological treat- ments. On the basis of the existing data, it can be assumed that the efficacy of chemo- therapy (induction of tumour cellular apop- tosis) can be increased as a result of in- travascular laser therapy. Further investiga- tions are planned in this regard.

Intravascular laser blood irradiation and the bioimmunotherapy according to Tall- berg appear to have additive and synergistic effects in the redifferentiation of tumour cells. The bioimmunotherapy exerts effects on tumour cell mitochondria. By means of mitochondria-nuclear communication malignantly transformed cells can regain their normal gene expression. Intravascular laser blood irradiation changes mitochondria morphologically and activates metabolic energy processes. In an application study these two methods were compared with each other both individually and in combina- tion in maximally chemotherapeutically pre-treated tumour patients. Clinically and morphologically synergistic and additive effects were observed.

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